Literature summary for 2.7.1.94 extracted from

Wang, X.; Lin, C.; Zhao, X.; Liu, A.; Zhu, J.; Li, X.; Song, L.
Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor (2014), Mol. Cancer, 13, 106.

Search for more literature for 2.7.1.94

Cloned(Commentary)

Cloned (Comment)	Organism
gene agk, quantitative real-time PCR enzyme expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + acylglycerol	Homo sapiens	-	ADP + acyl-sn-glycerol 3-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q53H12	gene agk	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	enzyme overexpression	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
SKBR-3 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + acylglycerol	-	Homo sapiens	ADP + acyl-sn-glycerol 3-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
AGK	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme overexpression significantly enhances, whereas silencing endogenous enzyme AGK inhibits the proliferation and tumorigenicity of breast cancer cells both in vitro and in vivo. Overexpression of AGK enhances G1-S phase transition in breast cancer cells, which is associated with activation of AKT, suppression of FOXO1 transactivity, downregulation of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 and upregulation of the cell cycle regulator cyclin D1	Homo sapiens
physiological function	acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor, FOXO1 is considered to be a tumor suppressor. The enzyme significantly correlates with patients' clinicopathologic characteristics, including clinical stage and tumor-nodule-metastasis (TNM) classification	Homo sapiens

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Release 2023.1 (January 2023)